Interstitial granulomatous nephritis is the most typical histological finding, but development of renal insufficiency is unusual, while the most important cause of renal dysfunction is a disordered calcium metabolism. The incidence of renal involvement ranges from 23% up to 48% with a wide spectrum of abnormalities. However sarcoidosis is associated with a broad spectrum of renal manifestations beyond granulomatous interstitial nephritis. The characteristic presentation of sarcoidosis is noncaseating granulomas, predominantly in the lungs and intrathoracic lymph nodes, but also in kidney interstitium. Sarcoidosis is neither a malignant nor an autoimmune disease, however, both genetic and environmental factors seem to play a role, and reaction to an unidentified antigen is suspected, despite the cellular immune response occurs in the absence of a clearly defined immunological target. The cause of the disease is not known - as yet, no bacterial, fungal, or viral antigen has been consistently isolated from the sarcoidosis lesions. Sarcoidosis is a systemic disease, affecting predominantly lungs and intrathoracic lymph nodes (75-90%), but also involving many other organs, including skin, eyes, bone marrow, liver, spleen, nose, throat, salivary glands, joints, central nervous system, heart, endocrine and gastrointestinal system, and also kidneys. Sarcoidosis, granulomas, interstitial nephritis, h ypercalcaemia, kidney stones, corticosteroids Background We present a case of sarcoidosis with both interstitial granulomas and kidney stones, complicated by acute kidney injury, and successfully treated with corticosteroids. Treatment is always required for renal and other end-organ damage corticosteroids are the mainstay of therapy. Interstitial granulomatous nephritis is the most typical finding another characteristic feature is kidney damage due to disordered calcium homeostasis, driven by calcitriol hyperactivity of macrophages, and leading to acute kidney injury, nephrocalcinosis, nephrolithiasis, tubular dysfunction etc. Sarcoidosis is associated with a broad spectrum of extrapulmonary involvement, including renal manifestations. Sarcoidosis is a systemic disease with unknown cause, characterized by noncaseating granulomas, predominantly in the lungs and intrathoracic lymph nodes.
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